Low Dose D-penicillamine in Cystinuria

Further Observations on Use of D-penicillamine in Cystinuria.

It was shown in a previous communication (Crawhall et al., 1963) that the abnormally high level of cystine excretion found in homozygotes for cystinuria could be reduced for short periods by the administration of D-penicillamine. This paper reports the results of administering the drug continuously to a group of cystinuric patients for periods of five months to one year. We have used the D-isom...

The use of D-penicillamine in cystinuria: efficacy and untoward reactions.

A retrospective study was conducted to assess the efficacy of D-penicillamine in the management of cystinuria, as well as to define the frequency and nature of untoward reactions to this drug. Fifty-six individuals were identified who, by stone analysis and/or biochemical studies, met the accepted diagnostic criteria for phenotypic cystinuria. The majority of these patients presented in the sec...

New Agent in the Treatment of Cystinuria: N-acetyl-D-penicillamine.

D-penicillamine in rheumatoid arthritis.

D-penicillamine (D-pen) has gained wide-spread use as a potent suppressor of disease activity in rheumatoid arthritis (RA) and juvenile chronic arthritis (JCA). The drug has been established for antirheumatotd therapy on the basis o f a considerable number o f comparative clinical studies o f D-pen treatment versus placebo or other disease modifying antirheumatic drugs (DMARDs). Despite the pos...

[D-penicillamine in rheumatoid arthritis].

In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis.